What Is ALK Fusion - FISH Test?

The ALK Fusion - FISH Test is a specialized molecular diagnostic test used to identify ALK gene rearrangements in patients with non-small cell lung cancer (NSCLC). These gene fusions can cause abnormal cell growth and cancer progression but are highly responsive to targeted treatments such as Crizotinib, Alectinib, and Ceritinib.

Using the Fluorescence In Situ Hybridization (FISH) technique, this test visually detects changes in the ALK gene in tumor tissue, providing vital information for personalized cancer treatment.

Why Choose ALK FISH Test In Dubai?

? Gold Standard For ALK Detection In NSCLC
? Guides Targeted Therapy With ALK Inhibitors
? High Specificity Using FISH Technology
? Available In Dubai’s Top Molecular Labs & Cancer Centers
? Globally Accepted Test By NCCN, CAP & ASCO
? Quick Turnaround – 5 To 7 Working Days

Who Should Get The ALK Fusion FISH Test?

✔️ Patients With Newly Diagnosed Non-Small Cell Lung Cancer (NSCLC)
✔️ Individuals With Adenocarcinoma Subtype Of Lung Cancer
✔️ Younger Patients Or Non-Smokers With Lung Cancer
✔️ Patients Testing Negative For EGFR, KRAS, Or ROS1 Mutations
✔️ Individuals Considering Or Currently On Targeted ALK Inhibitors

Benefits Of ALK Fusion FISH Test

✨ Detects ALK Gene Rearrangements Accurately
✨ Enables Access To Advanced Targeted Therapies
✨ Non-Invasive – Uses Existing Biopsy/Surgical Tissue Sample
✨ Improves Treatment Outcomes & Patient Survival
✨ Globally Recognized & Clinically Validated

Procedure Of The Test

1. Sample Collection

   • The test is performed on a formalin-fixed, paraffin-embedded (FFPE) tumor tissue sample from a biopsy or surgery.

2. Probe Hybridization

   • Fluorescent DNA probes are applied to detect ALK gene breaks or fusions on the chromosomes.

3. Fluorescence Microscopy

   • A pathologist examines the stained sample under a fluorescence microscope to determine gene rearrangement.

4. Result Reporting

   • A positive result confirms ALK rearrangement and eligibility for ALK-targeted therapies.

Methodology Of The Test

The ALK Fusion Test uses FISH (Fluorescence In Situ Hybridization), a powerful cytogenetic method to detect gene fusions at the DNA level.

? Technique Highlights:

• Uses dual-labeled break-apart probes targeting the ALK gene on chromosome 2

• If the probes show separation (split signals), ALK gene rearrangement is present

• Interpretation performed by a certified molecular pathologist

? This method is:

• Highly accurate and sensitive

• Recommended by international oncology guidelines

• Used to determine eligibility for ALK inhibitors like Crizotinib, Alectinib, Lorlatinib, etc.

Conclusion

The ALK Fusion - FISH Test is a life-changing genetic test that plays a critical role in managing non-small cell lung cancer in Dubai. By detecting ALK gene rearrangements, it enables oncologists to prescribe targeted therapies that are more effective and less toxic than traditional chemotherapy.

? If you or a loved one has been diagnosed with lung cancer, consider the ALK FISH test to unlock personalized treatment options and improved survival.